PRP Tube ine Gel
Tsanangudzo Pfupi:
Abstract.Autologousplatelet-rich plasma(PRP) gel iri kuwedzera kushandiswa mukurapa kwezvakasiyana-siyana zvakapfava uye bony tissue defects, zvakadai sekukurumidza kuumbwa kwepfupa uye mukugadzirisa maronda asingagumi asina kupora.
Masero ese eropa anobva kune yakajairwa pluripotent stem cell, inopatsanurwa kuita mitsara yesero.Imwe neimwe yeaya maseru akatevedzana ane precursors anogona kupatsanura uye kukura.
Platelets, anonziwo thrombocytes, anokura kubva mumwongo.Maplatelet ane nucleated, discoid cellular elements ane hukuru hwakasiyana uye density inosvika 2 μm mudhayamita, idiki density yemasero ese eropa.Huwandu hwefiziology hwemaplatelet anotenderera murukova rweropa kubva pa150,000 kusvika ku400,000 maplatelet pa μL.
Maplatelet ane akati wandei ekuvanzika granules akakosha pakushanda kweplatelet.Kune marudzi matatu emagranules: dense granules, o-granules, uye lysosomes.Muplatelet yega yega mune angangoita 50-80 granules, iyo yakanyanya kuwanda yemhando nhatu dzegranules.
Platelets ndiwo anonyanya kuita basa rekuunganidza.Basa guru nderekubatsira kune homeostasis trough 3 maitiro: adhesion, activation, uye aggregation.Munguva yekukuvadzwa kwevascular, maplatelet anogadziriswa, uye magranules avo anoburitsa zvinhu zvinokurudzira coagulation.
Maplatelet aifungidzirwa kuti ane basa rehemostatic chete, kunyange mumakore achangopfuura, tsvakurudzo yesayenzi uye teknolojia yakapa maonero matsva pamaplatelet nemabasa avo.Zvidzidzo zvinoratidza kuti maplatelet ane huwandu hweGF uye macytokines anogona kukanganisa kuzvimba, angiogenesis, stem cell migration, uye kuwedzera kwesero.
PRP inzvimbo yechisikigo yekusaina mamorekuru, uye pakushandiswa kwemaplatelet muPRP, maP-granules anonatswa uye anoburitsa maGF uye ma cytokines anozo shandura iyo cellular microenvironment.Mamwe eGF anonyanya kukosha akabudiswa nemaplatelet muPRP anosanganisira vascular endothelial GF, fibroblast GF (FGF), platelet-derived GF, epidermal GF, hepatocyte GF, insulin-like GF 1, 2 (IGF-1, IGF-2), matrix metalloproteinase 2, 9, uye interleukin 8.
