HA PRP Collection Tube
Tsanangudzo Pfupi:
HA is hyaluronic acid, inowanzozivikanwa se hyaluronic acid, yakazara Chirungu Zita: hyaluronic acid.Hyaluronic acid ndeyemhuri yeglycosaminoglycan, iyo inoumbwa neinodzokororwa disaccharide units.Ichatorwa nekuora nemuviri wemunhu.Nguva yekuita kwayo yakareba kupfuura iyo ye collagen.Inogona kurebesa nguva yekuita kuburikidza nekuyambuka-kubatanidza, uye mhedzisiro inogona kugara kwemwedzi 6-18.
Iyo huru pathophysiological shanduko yemabvi osteoarthritis kurasikirwa kwecartilage, subchondral bone rekuvaka, osteophyte kuumbwa uye synovial inflammatory reaction.Makiriniki ekutanga kuratidzwa kuzvimba, kurwadziwa uye kuoma kwemajoini uye akapoteredza tishu.Nekufambira mberi kwechirwere, zvishoma nezvishoma zvinotungamirira kuhutano hwekubatana uye zvinokanganisa zvakanyanya mararamiro ehupenyu.Maererano neongororo iyi, hurema hwepasi rose hwe osteoarthritis hwakanga huri 2.2% muna 2010, uye huwandu hwevanhu vakaremara mugore rimwe chete hwakapfuura 1.7 miriyoni, izvo zvakaunza kukuvadza kwakakomba munharaunda, mhuri uye vanhu.HA ndeyepamusoro molecular polysaccharide biomaterial inoumbwa nekudzokororwa kuchinjwa kwen-acetylglucuronic acid.Icho chikamu chikuru chejoint synovial fluid uye chimwe chezvikamu zve cartilage matrix.Inoita basa mukudya uye kudzivirira majoini.HA mukurapwa kweosteoarthritis yave ichiratidzwa nekiriniki kuti ine imwe mhedzisiro pakubvisa zviratidzo zvemabvi uye kuvandudza kufamba kwemabvi.Zvisinei, nekuda kwekushayikwa kwehupupu-based support, kunyanya kusava nechokwadi kwekushanda kwenguva refu, mazano ekupedzisira eAAOS ekuongororwa uye kurapwa kwemabvi osteoarthritis haakurudziri kushandiswa kwehyaluronic acid, uye nhanho yekukurudzira inokurudzirwa zvakasimba.Triamcinolone acetonide, seyakareba-inoita synthetic glucocorticoid, ine simba uye rinogara risingaperi rinopesana nekuputika.
Nzira yaro ndeyokudzivisa phagocytosis uye kushandiswa kwemaantigen nema macrophages;Gadzirisa lysosomal membrane uye kuderedza kusunungurwa kwe hydrolase mu lysosome;Inhibisa kutama kweleukocytes uye macrophages kunze kwemidziyo yeropa uye kuderedza kuzvimba kuita.Ichi chidzidzo chinoratidza kuti mhedzisiro ye intra-articular jekiseni ye triamcinolone acetonide yakanaka mukati memwedzi mumwe mushure mekurapa, asi nenguva yekurega, kunyanya mushure memwedzi mitanhatu yekurapa, mhedzisiro yacho yakanyanya kuderera kune mamwe mapoka maviri.Mcalindon nezvimwe zvidzidzo zvakaratidza kuti kune varwere vane zviratidzo vane mabvi osteoarthritis, intraarticular jekiseni ye triamcinolone acetonide yakakonzera kurasikirwa kukuru kwecartilage uye hapana musiyano mukuru mukurwadziwa kwemabvi kana ichienzaniswa nesaline yakajairika.
Zvidzidzo zviri pamusoro hazvitsigire kurapwa uku kwevarwere vane symptomatic vane knee osteoarthritis.Vamwe vatsvakurudzi vakashandisa triamcinolone acetonide uye sodium hyaluronate intra-articular jekiseni kurapa mabvi osteoarthritis, uye kushanda kwayo kwenguva pfupi uye kwenguva refu zviri nani pane iyo hyaluronic acid chete.Semushonga mutsva, PRP inogona kuwanikwa kubva kuvarwere 'autologous peripheral blood, pasina kurambwa kwekudzivirira, uye ine huwandu hwakanyanya hwekukura kwezvinhu.Kukura kwezvinhu zvakaratidzwa kukurudzira chondrocyte kuwanda uye extracellular matrix synthesis.Uyezve, zvidzidzo zvenguva pfupi zvakaratidza kuti PRP inogona kudzivisa hutachiona hwekusununguka kwe synovium kune imwe nzvimbo apo ichikurudzira chondrocyte regeneration.Kuwedzera kwekuedza kwemhuka uye zvidzidzo zvekiriniki zvinoratidza kushanda kwayo kwakanaka.Ichi chidzidzo chinoratidza kuti chikamu cheWOMAC chePRP pa1 uye 3 mwedzi mushure mekurapwa yakaenzana neye hyaluronic acid, uye chikamu cheWOMAC chePRP pamwedzi mitanhatu mushure mekurapwa chiri nani pane chemamwe mapoka maviri, zvichiratidza kuti ine yakanaka yepakati uye yenguva refu yekurapa maitiro.Zvisinei, nekuda kwekushayikwa kwenguva refu kwekliniki yekutevera zvidzidzo zvemasampuli makuru uye kushayikwa kwerutsigiro rwakananga kubva kune imwezve molecular biology kana MRI imaging, kumwe kutsvakurudza nekukurukurirana kuchiri kudiwa.
