IGFs uye bioactive molecules iripo muPRP inokurudzira 4 zviito zvikuru munharaunda yemunharaunda yehutungamiri, zvakadai sekuwedzera, kutama, kusiyanisa masero, uye angiogenesis.Ma cytokines akasiyana uye maGF anobatanidzwa mukugadzirisa kwebvudzi morphogenesis uye kutenderera bvudzi kukura.
Iyo dermal papilla (DP) masero anogadzira maGF akadai IGF-1, FGF-7, hepatocyte growth factor, uye vascular endothelial growth factor iyo inotarisira kuchengetedza follicle yebvudzi muchikamu cheanagen chekutenderera kwebvudzi.Naizvozvo, chinangwa chinogona kunge chiri chekusimudzira maGF aya mukati meDP masero, ayo anorebesa chikamu cheanagen.
Maererano nekuongorora kwakaitwa naAkiyama et al, epidermal growth factor uye kushandura kukura kwekukura kunobatanidzwa mukugadzirisa kukura uye kusiyanisa kwemasero emagetsi, uye platelet-derived growth factor inogona kuva nemabasa akaenzana mukubatana pakati pekuputika uye mashizha akabatanidzwa, kutanga ne follicle morphogenesis.
Kunze kweGFs, chikamu cheanagen chinoshandiswawo neWnt/β-catenin/T-cell factor lymphoid enhancer.Mumasero eDP, kushandiswa kweWnt kuchaita kuti kuunganidza β-catenin, iyo, pamwe chete neT-cell factor lymphoid enhancer, inoshandawo se-co-activator yekunyora uye inokurudzira kupararira, kurarama, uye angiogenesis.Masero eDP anobva atanga kusiyanisa uye nekudaro shanduko kubva kutelogen kuenda kuchikamu cheanagen.β-Catenin siginecha yakakosha mukukura kwefollicle yemunhu uye yekukura kwebvudzi.
Imwe nzira inoratidzwa muDP ndeye activation ye extracellular signal-regulated kinase (ERK) uye protein kinase B (Akt) siginecha inosimudzira kurarama kwesero uye kudzivirira apoptosis.
Iyo chaiyo nzira iyo PRP inokurudzira kukura kwebvudzi haina kunyatsonzwisiswa.Kuongorora nzira dzinogoneka dzakabatanidzwa, Li et al, akaita chidzidzo chakanyatsogadzirwa kuti aongorore mhedzisiro yePRP pakukura kwebvudzi uchishandisa in vitro uye in vivo modhi.Mune in vitro modhi, activated PRP yakaiswa kumunhu DP masero akawanikwa kubva kune yakajairika ganda remusoro wemunhu.Zvigumisiro zvakaratidza kuti PRP yakawedzera kuwanda kwevanhu DP masero nekuita ERK uye Akt kusaina, zvichiita kuti antiapoptotic madhara.PRP yakawedzerawo β-catenin basa uye FGF-7 kutaura muDP masero.Nezve in vivo modhi, mbeva dzakaiswa jekiseni neyakagadzirwa PRP dzakaratidza kukurumidza telogen-kune-anagen shanduko mukuenzanisa neboka rinodzora.
Munguva ichangopfuura, Gupta naCarviel vakakurudzirawo nzira yekuita kwePRP pamafollicles evanhu anosanganisira "kutsvaga kweWnt / β-catenin, ERK, uye Akt zviratidzo zvenzira dzinokurudzira kupona kwesero, kupararira, uye kusiyanisa."
Mushure mekunge GF yasunga nemunyori wayo GF receptor, kusaina kunodiwa pakutaura kwayo kunotanga.Iyo GF-GF receptor inomutsa kutaura kwezvose Akt uye ERK kusaina.Kushandiswa kweAkt kuchadzivisa nzira dze 2 kuburikidza nephosphorylation: (1) glycogen synthase kinase-3β inokurudzira kuora mwoyo kwe β-catenin, uye (2) Bcl-2-yakabatana nerufu inosimudzira, iyo inokonzera kukonzera apoptosis.Sezvakataurwa nevanyori, PRP inogona kuwedzera vascularization,kudzivirira apoptosis, uye kuwedzera nguva yeanagen chikamu.
Nguva yekutumira: Aug-24-2022